Study Type :. Interventional Clinical Trial. Actual Enrollment :. Study Start Date :. Actual Primary Completion Date :. Actual Study Completion Date :. Active Comparator: Arm 1 0. Drug: Bone morphogenetic protein 7 Comparison of different doses of the drug via single intraarticular knee injection. Active Comparator: Arm 2 0.
Active Comparator: Arm 3 0. Placebo Comparator: Arm 4 1 ml placebo, single intraarticular knee injection control. Drug: Placebo Placebo. Duncansville, Pennsylvania, United States, West Reading, Pennsylvania, United States, April 27, Key Record Dates.
Secondary Outcome Measures : Doubling of serum creatinine 2 Need for dialytic support 3 Patient death 4 Comparison of urinary markers of renal injury in subjects in study group vs. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Inclusion Criteria: Subjects age 18 and over and of either gender.
Scheduled to receive CT scan with intravenous contrast dye. Non diabetics or subjects with type 1 or 2 diabetes mellitus Written informed consent. Subjects who are on diuretics and non-steroidal inflammatory agents will not be excluded. Subjects who have received n-acetylcysteine or sodium bicarbonate pre CT scan will not be excluded Exclusion Criteria: Pregnant or lactating women. Subjects receiving peritoneal dialysis or hemodialysis.
Subjects with a known hypersensitivity or anaphylaxis to contrast dye or iodine. Subjects with known hypersensitivity or anaphylaxis to erythropoietin, mammalian-cell derived products, or human albumin. Evidence of hemodynamic instability Subject unable to follow protocol due to mental incompetence or other reason Inaccessibility of medical record Subjects with a history of MI, CVA, active angina or unstable angina within the past three months Subjects with a history of current malignancy, where current malignancy is defined as subjects undergoing treatment with chemotherapy or radiation therapy, subjects with known metastatic disease, and those with terminal malignant disease.
Subject with any known history of seizure disorders. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.
Frank Baker 0. Add your name now! Frank Baker 0 Comments. Almost there! Add your voice! Maxine K. Adam B. BMP-7 Support My dad has renal failure stage 5. I have been looking everywhere and researching things and I have come across articles about BMP We would be more than happy to help on any effort that would expedite the release of that medicine to the public use.
Do you know of any opportunities for participation in clinical trials. I know he would be happy to do that. Comment Post Cancel. BMP protein hey i m an indian and i m excited about this protein. I would be glad to participate, please send me the instructions on how to do it. Ortho sat on the kidney project for over four years. Curis got control back as of August 18th, and apparently are looking for a new Licensee to go forward with the project.!
I am appealing to other Kidney Patients, and to their families to help spread the word that a probable cure for kidney disease exists..! We should have been involved in trials long ago.! Maybe some of us would all ready have been cured.!
We need ALL the publicity we can get..!! Stryker is the same corporation that uses BMP-7 for bone fractures.
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